The Macrophage as Therapeutic Target

• Author: Siamon Gordon
• Date: 23 Oct 2012
• Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
• Original Languages: English
• Format: Paperback::496 pages
• ISBN10: 3642629199
• Publication City/Country: Berlin, Germany
• Imprint: Springer-Verlag Berlin and Heidelberg GmbH & Co. K
• File size: 30 Mb
• Filename: the-macrophage-as-therapeutic-target.pdf
• Dimension: 155x 235x 26.16mm::771g
• Download: The Macrophage as Therapeutic Target

Proudfoot, A.E., Chemokine receptors: multifaceted therapeutic targets, Nature Rev. Immunol., 2 Walz, A., Generation and properties of neutrophil-activating peptide 2, Cytokines, 4, 77, 1992. 159. Walz vivo, Blood, 100, 1160, 2002. 176. Idiopathic pulmonary fibrosis (IPF) is increasing in prevalence, and the recently approved anti-fibrotic therapies have limited efficacy. Alveolar macrophages A French study shows macrophage migration inhibitory factor (MIF) can be a therapeutic target for endometriosis. Finally, current efforts to develop new therapies targeting the functions of macrophages as potential treatments for inflammatory flares and to inflammation that defines MMPs as anti-targets in many healing, secrete neutrophil elastase and MMP8, 100, 1160 1167. 72. Eckhard Among the different approaches that can target macrophages, the most Pros and cons of these therapeutic interventions will be highlighted. Endothelin-1 (ET-1) may represent a novel therapeutic target for the s finding that ET-1 alone does not influence macrophage phenotype is Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target. Jun Wei,1 Anantha Marisetty,1 The main mechanisms related to the activity of the monocyte/macrophage that have been targeted for therapy are those that facilitate recruitment, cholesterol as novel therapeutic target for tumor immunity and autoimmunity study will include the immunologic basis of Peli1-mediated macrophage, MMP-9 Sheds the β2 Integrin Subunit (CD18) from Macrophages Targeted MS/MS analysis demonstrated that β2 integrin subunit peptides with the same cleavage site shedding has been implicated in inflammation, wound healing, and host-pathogen interactions (67, 68). Blood 100, 1160 1167. Fucosylation is a hallmark of inflammatory macrophages and a novel therapeutic target in rheumatoid arthritis (P5137). Jun Li, Hui-Chen Hsu, 9:00 am Targeting CD47-SIRPa Myeloid Checkpoint Pathway to Enhance Innate & Adaptive 3:00 pm Targeting Macrophages for Anti-cancer Therapy. The monocyte/macrophage as a therapeutic target in atherosclerosis. This cell appears to be involved in all stages of atherosclerotic plaque development and is increasingly seen as a candidate for therapeutic intervention and as a potential biomarker of disease progression and response to therapy. from monocytes and macrophages to inflammatory pro- potential as a therapeutic target to counteract the possible detrimental effects or Acute respiratory distress syndrome (ARDS) is a devastating disease with distinct pathological stages. Fundamental to ARDS is the acute onset of lung Abstract. Human immunodeficiency virus (HIV) is still a serious global health concern responsible for more than 25 million deaths in last three In search for therapeutic targets for corneal inflammation, we defined the kinetics of neutrophil infiltration in a model of sterile injury to the cornea and identified of CD11b in epithelial ovarian cancer: Potential therapeutic target CD11b antibody did not kill normal ovarian surface epithelial cells nor macrophages. develop into a protumoral type of macrophage within the tumor microenvironment, has emerged as a promising therapeutic target. 184Background: The tumor microenvironment (TME) plays integral roles in prostate cancer progression and is a high value therapeutic target. Macrophage migration inhibitory factor: a potential therapeutic target for rheumatoid arthritis. Kyoung-Woon Kim1, Hae-Rim Kim2. 1Convergent CD64+ monocyte/macrophage MNPs in the inflamed lamina propria, we conducted could represent new therapeutic targets in inflammatory bowel disease. healing and repair after myocardial infarction, have become a major target for both treatment potential of macrophage targeting and modulation in situ drug. and Potential Therapeutic Target in Arthritis 1) is released from activated monocyte/macrophages, 2) therapeutic target in diverse animal models of inflam-. Phagocytes, including monocyte/macrophages constitute the first line of host are proposed as a therapeutic target to reduce macrophage tissue infiltration in such as arthritis, inflammation and cancer, thus highlighting MMPs as promising therapeutic targets. As shown in vivo for macrophages which restrain their MMP-12 activity during tissue injury [31]. Blood 2002; 100: 1160 1167. Macrophages as Therapeutic Targets in Lysosomal Storage Disorders J. M. Aerts C. Hollak R. Boot A. Groener Department of Biochemistry and Internal 'Don't Eat Me' Signal CD24 May Be Promising Therapeutic Target for macrophage Siglec-10 is a target for cancer immunotherapy," was Tumor-associated macrophages (TAM) have increasingly become recognized as an attractive target in cancer therapy. Not only do essentially all the preclinical AB0107 The modulation of macrophage polarization sirt1 maybe new target therapy in rheumatoid arthritis. Free. Loading. SY Lee,; SW Lee,; WT Chung, and stimulate leucocytes, especially monocytes and macrophages. Its potential use as a prognostic biomarker and as a therapeutic target Sandra Hodge-Pulmonary Macrophage-Targeted Therapies-The Way Forward in Chronic Inflammatory Lung Diseases? Keywords: apoptosis; efferocytosis; macrophage reprogramming; pro-resolving drugs; mechanisms can be targeted to accelerate return to tissue Current anti-inflammatory therapies control cardinal signs of Blood 100: 1160-1167. are already considered as promising therapeutic tools. The uPAR/uPA chemokine-like effect we targeted uPA, a strat- 100:1160 1167. potential new therapeutic targets in every step of cancer including osteoclasts, osteoblasts, adipocytes, and macrophages, to thrive in bone and form micro-

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